Calogero Gambino, 41, was found hanging by the neck from a stairway banister, reports the Wall Street Journal.
He was found by his wife, and pronounced dead at the scene, New York City officials told the paper.
Gambino, an associate general counsel and managing director, had worked for Deutsche Bank for 11 years.
He had worked closely for the bank on legal issues relating to the Libor scandal, after regulators started investigating the company in 2012.
He was also an associate at a private law firm and a regulatory enforcement lawyer between 1997 and 1999, the Wall Street Journal reports, citing Gambino's LinkedIn profile and conference biographies.
"Charlie was a beloved and respected colleague who we will miss. Our thoughts and sympathy are with his friends and family," Deutsche Bank said in a statement.
The bank has been battling allegations that employees manipulated the Libor benchmark interest rate as well as currency markets.
The bank, which is Germany's biggest lender, has paid €6.1bn (£4.8bn) in fines and settlements since the manipulation was exposed two and a half years ago.
In the third quarter of 2014, the bank's litigation costs are expected to come to €894m.
This week, the bank is believed to have reached a settlement to pay a further €1bn in a settlement with US and and UK financial authorities.
Gambino is the second Deutsche Bank employee to have committed suicide this year, after former manager William Broeksmit, 58, was found dead in his London home, having hung himself.
A coroner found in March that Broeksmit had been closely involved in the Libor probe, and was anxious about the investigations by financial authorities.
A bank spokesman said at the time of the inquest that Mr Broeksmit "was not under suspicion of wrongdoing in any matter."
At the time of his death, executives sent a memo to bank colleagues describing Mr Broeksmit "was considered by many of his peers to be among the finest minds in the fields of risk and capital management."